The Center for Structural Genomics of Infectious Diseases

The JCVI has been a consortium member of the Center for Structural Genomics of Infectious Disease (CSGID) sponsored by the National Institute for Allergy and Infectious Disease (NIAID) since 2007. The Center's mission is to solve the three-dimensional structure of proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The targeted proteins are those with an important biological role or potential targets for vaccine and drug development.

The JCVI CSGID team has developed a high-throughput (HTP) cloning and protein expression pipeline to screen protein candidates for downstream scaled-up expression, protein purification and ultimately HTP structural determination. Clones yielding expressed, soluble protein are transferred to our consortium members who in turn apply state-of-the-art HTP structural biology technologies to experimentally determine the three-dimensional atomic structure. The three-dimensional structure of proteins will assist drug design and development by yielding direct insights into the target molecular mechanisms for interaction with other biological molecules or with synthetic compounds, in order to improve selectivity, specificity and optimize drug development in a rational way.

An individual or collaborative group of investigators interested in proposing a target for protein structure determination at the CSGID can submit a proposal to CSGID through

Available Organisms

Viruses Taxon ID
Cowpox virus (Brighton Red) 265872
Dengue virus 1 11053
Dengue virus 2 11060
Dengue virus 3 11069
Dengue virus 4 11070
Human herpesvirus 6 10368
Monkeypox virus 10244
Myxoma virus (strain Lausanne) 31530
Influenza virus A 197911
Prokaryotes Taxon ID
Acinetobacter baumannii ATCC 17978 400667
Actinobacillus pleuropneumoniae 228399
Bacillus anthracis str. Ames 198094
Bacillus anthracis str. Sterne 260799
Bacillus cereus ATCC 10987 222523
Bacillus cereus ATCC 14579 226900
Bacillus subtilis subsp. subtilis str. 168 224308
Bacteroides thetaiotaomicron VPI-5482 226186
Bifidobacterium infantis Reuter 391904
Bordetella pertussis Tohama I 257313
Borrelia burgdorferi B31 224326
Burkholderia mallei ATCC 23344 243160
Campylobacter jejuni subsp. jejuni NCTC 11168 192222
Chlamydia muridarum MoPn Nigg II 243161
Chlamydia trachomatis D/UW-3/CX 272561
Chlamydia trachomatis D/UW-3/CX 272561
Clostridium difficile 630 272563
Clostridium perfringens ATCC 13124 195103
Cowpox virus Brighton Red 265872
Coxiella burnetii RSA 493 227377
Enterococcus faecinum TEX16, TX0016 333849
Enterococcus faecalis V583 226185
Escherichia coli 042 216592
Escherichia coli CFT073 199310
Escherichia coli ETEC H10407 316401
Escherichia coli K12 substr. MG1655 511145
Escherichia coli O157:H7 EDL933 155864
Escherichia coli O157:H7 str. Sakai 386585
Escherichia coli UTI89 364106
Francisella tularensis subsp. tularensis SCHU S4 177416
Haemophilus influenzae PittII 374933
Helicobacter pylori 26695 85962
Helicobacter pylori Str RPH 13487 102618
Helicobacter pylori J99 85963
Legionella pneumophila susp.pneumophila str.Philadelphia 1 272624
Listeria monocytogenes 1/2a F6854 267409
Listeria monocytogenes EGD-e 169963
Listeria monocytogenes str. 4b F2365 265669
Listeria monocytogenes str. 4b H7858 267410
Mycobacterium smegmatis str. MC2 155 246196
Mycobacterium tuberculosis CDC1551 83331
Mycobacterium tuberculosis H37Rv 83332
Neisseria gonorrhoeae FA 1090 242231
Neisseria meningitidis MC58 122586
Pseudomonas aeruginosa PA14 652611
Pseudomonas aeruginosa PAO1 208964
Pseudomonas fluorescens Pf-5 220664
Pseudomonas putida KT2440 160488
Rickettsia prowazekii str. Madrid E 272947
Rhizobium radiobacter/Agrobacterium tumefaciens str C58 176299
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 295319
Salmonella enterica subsp. enterica serovar Typhi str. CT18 220341
Salmonella enterica subsp. enterica serovar Typhi Ty2 209261
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 99287
Shigella flexneri 2a str. 2457T 198215
Staphylococcus aureus Strain FPR3757 451515
Staphylococcus aureus subsp. aureus COL 93062
Staphylococcus aureus subsp. aureus MRSA252 282458
Staphylococcus aureus subsp. aureus 923 875057
Staphylococcus aureus subsp. aureus Mu3 418127
Staphylococcus aureus subsp. aureus Mu50 158878
Staphylococcus aureus subsp. aureus MW2 196620
Staphylococcus aureus substp.aureus N315 1558879
Staphylococcus aureus substp.aureus NCTC 8325 93061
Staphylococcus epidermidis RP62A 176279
Streptococcus agalactiae Str A909 205921
Streptococcus agalactiae 2603V/R 208435
Streptococcus mutants UA 159 210007
Streptococcus pneumoniae G54 512566
Streptococcus pneumoniae R6 171101
Streptococcus pneumoniae TIGR4 170187
Streptococcus pyogenes Strain NZ131 471876
Streptococcus pyogenes MGAS5005 293653
Streptococcus salivarius subsp. thermophilus Strain LMD-9 322159
Streptococcus thermophilus LMG18311 264199
Vibrio cholerae O1 biovar El Tor str. N16961 243277
Vibrio cholerae O395 345073
Vibrio fischeri ES114 312309
Vibrio parahaemolyticus EB101 670
Vibrio parahaemolyticus RIMD 2210633 223926
Vibrio vulnificus CMCP6 216895
Yersinia enterocolitica str 8081 393305
Yersinia pestis CO92 214092
Yersinia pestis KIM 187410
Yersinia pseudotuberculosis IP 32953 273123


This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272200700058C and HHSN272201200026C.

CSGID Consortium



Collaborators may access the most current clones.xml and expressions.xml data files through our FTP site (password required).

Web access:

Linux command line:
% ftp

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