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1st Minimal Cell Workshop
View complete playlist for the workshop on YouTube. Day 1 — September 20, 2021 Time PDT Video Title Presenter Organization PI 5:00 - 5:15 Welcome and introduction John Glass 5:15 - 5:27 Restoring complete pyruvate hydrogenase gene to JCVI-syn3A increases growth rate as predicted by FBA whole cell computational model ...
2nd Minimal Cell Workshop
View complete playlist for the workshop on YouTube. Day 1 — September 22, 2022 Time PDT Video Title Presenter Organization PI 5:00 - 5:15 Welcome and introduction John Glass 5:15 - 5:30 Cell-free expression system derived from Syn3A cells Andrei Sakai Radboud University Wilhelm Huck ...
NLM Selects Dr. Richard H. Scheuermann as Scientific Director for the National Library of Medicine
Patricia Flatley Brennan, RN, PhD, Director of the National Library of Medicine (NLM) at the National Institutes of Health (NIH), has named Richard H. Scheuermann, PhD, as NLM’s new Scientific Director following a nationwide search. Dr. Scheuermann is currently the La Jolla campus director at the J. Craig Venter Institute (JCVI). He is expected to begin his role as NLM Scientific Director on September 10, 2023. “NLM is embarking on a bold new direction to optimize NLM’s vibrant...
Early detection of emerging SARS-CoV-2 variants of interest for experimental evaluation.
Since the beginning of the COVID-19 pandemic, SARS-CoV-2 has demonstrated its ability to rapidly and continuously evolve, leading to the emergence of thousands of different sequence variants, many with distinctive phenotypic properties. Fortunately, the broad application of next generation sequencing (NGS) across the globe has produced a wealth of SARS-CoV-2 genome sequences, offering a comprehensive picture of how this virus is evolving so that accurate diagnostics, reliable therapeutics, and...
Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T cell responses in humans.
The monkeypox virus (MPXV) outbreak confirmed in May 2022 in non-endemic countries is raising concern about the pandemic potential of novel orthopoxviruses. Little is known regarding MPXV immunity in the context of MPXV infection or vaccination with vaccinia-based vaccines (VACV). As with vaccinia, T cells are likely to provide an important contribution to overall immunity to MPXV. Here, we leveraged the epitope information available in the Immune Epitope Database (IEDB) on VACV to predict...
Introducing the Bacterial and Viral Bioinformatics Resource Center (BV-BRC): a resource combining PATRIC, IRD and ViPR.
The National Institute of Allergy and Infectious Diseases (NIAID) established the Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the growing body of genome sequence and other omics-related data. In this report, we describe the merger of the PAThosystems Resource Integration Center (PATRIC), the Influenza Research Database (IRD) and the Virus Pathogen Database and Analysis Resource (ViPR) BRCs to form the Bacterial and Viral Bioinformatics Resource Center...
NETome: A model to Decode the Human Genome and Proteome of Neutrophil Extracellular Traps.
Neutrophils are the most abundant type of white blood cells in humans with biological roles relevant to inflammation, and fighting off infections. Neutrophil Extracellular Traps (NETs) act as enxogenous agents controlling invasion by bacteria, viruses, fungi, metabolic, and traumatic agents. Traditionally, studies have focused on elucidating molecular and cellular pathways preceding NET formation. Here, we developed a model to decode the human genome and proteome of developted NETs. Via in...
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters.
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and biomaterials. The genes that encode these pathways are often organised into biosynthetic gene clusters (BGCs). In 2015, we defined the Minimum Information about a Biosynthetic Gene cluster (MIBiG): a standardised data format that describes the...
<i>mucG, mucH,</i> and <i>mucI</i> Modulate Production of Mutanocyclin and Reutericyclins in Streptococcus mutans B04Sm5.
Streptococcus mutans is considered a primary etiologic agent of dental caries, which is the most common chronic infectious disease worldwide. S. mutans B04Sm5 was recently shown to produce reutericyclins and mutanocyclin through the biosynthetic gene cluster and to utilize reutericyclins to inhibit the growth of neighboring commensal streptococci. In this study, examination of S. mutans and phylogeny suggested evolution of an ancestral S. mutans into three lineages within one S. mutans clade...
Minimal Cell Workshop
5th Minimal Cell Workshop The Minimal Cell Workshop virtual series is an annual event that brings together the worldwide community of researchers working with JCVI's minimized cell, JCVI-syn3.0 (or one of its variants). JCVI-syn3.0 is based on the naturally occurring Mycoplasma mycoides, but with roughly half as many genes. This model organism has proven to be a platform for exploring the first principles of life, a chassis for engineering, computational modeling, and more. Interested in...