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Everybody is Kung-Flu Fighting: Deep Sequencing of Clinical Influenza A Virus Reveals Patterns of Emerging/ Re-emerging Amino Acid Substitutions
Emma Roth, Brian Aevermann, Vinita Puri, Nadia Fedorova, Susmita Shrivastava, Lihui Wu, Paolo Amedeo, Rafael Medina, Gene Tan, Brett E. Pickett J. Craig Venter Institute, La Jolla, CA Infection by influenza A virus (IAV) can occur in birds or swine, and results in approximately 700,000 hospitalizations and 56,000 human deaths each year. Although vaccines exist and are reformulated each year, the rapid mutation rates (antigenic drift) and reassortment (antigenic shift) across...
Optimizing Phagehunting Methods to Isolate and Amplify Bacteriophages
Shriya Singh, Enrique Assad-Garcia, Nacyra Assad-Garcia, Lauren Oldfield, Sanjay Vashee, and Derrick E. Fouts J. Craig Venter Institute, Rockville, MD 20872 There are an estimated 1031 bacteriophages (phage), viruses that infect bacteria, in the biosphere, thus comprising a significant portion of the biosphere on Earth. Of these, a mere 10,733 phages have been isolated and 2,061 phages have sequenced, complete genomes, with even fewer, only 1,073,...
Genomic and Antigenic Analysis of Seasonal H3N2 Influenza a Virus From 2012-2013
Haley Hochstein1, Karla M. Stucker1, Seth Schobel2, Xudong Lin1, Randall J. Olsen3, Anju Subba1, Rebecca A. Halpin1, Asmik Akopov1, Nadia Fedorova1, Timothy B. Stockwell2, James M. Musser3, Suman R. Das1, David E. Wentworth1 1Virology Group and 2Informatics Department, J. Craig Venter Institute, Rockville, MD 20850 3Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX 77030 Influenza is an acute viral...
Generating a Library of Influenza a Virus Hemagglutanin and Neuraminidase Genes
Titas Bera, Anthony Bennici, Haley Hochstein, Karla M. Stucker, Suman R. Das, David E. Wentworth Virology Group, J. Craig Venter Institute, Rockville, MD 20850 Every year, five to twenty percent of the United States population is infected with seasonal influenza, making the construction of a seasonal vaccine of high importance. However, due to antigenic drift among seasonal influenza viruses, the vaccine strains need frequent updating. Antigenic drift occurs as the genes encoding...
Sequence-independent Amplification of Rotaviruses for High-throughput Next-generation Sequencing
Anthony K. Bennici1, Karla M. Stucker1, Asmik Akopov1, Nadia Fedorova1, Rebecca A. Halpin1, Timothy B. Stockwell2, David E. Wentworth 1Virology Group and 2Informatics Department, J. Craig Venter Institute, Rockville, MD 20850 Rotavirus is a segmented dsRNA virus that causes gastroenteritis and is the primary cause of severe pediatric diarrhea, which results in over half a million deaths per year globally. There are eight known species of rotaviruses (A-H) that infect humans and...
Translational Health Science and Technology Institute (THSTI) Training
In September 6-8, 2017, Translational Health Science and Technology Institute (THSTI), NIAID Division of Microbiology and Infectious Diseases (DMID) , NIAID PATRIC Bioinformatics Resource Center/University of Chicago and NIAID Genomic Center for Infectious Diseases at J. Craig Venter Institute participated in three days training in Delhi, India for Indo-US Workshop on Genomics and Bioinformatics to Explore Human Microbiome Ecology in Health and Diseases. The Translational Health Science and...
Key Biological Mechanism is Disrupted by Ocean Acidification
A team led by scientists from Scripps Institution of Oceanography at the University of California San Diego and the J. Craig Venter Institute (JCVI) has demonstrated that the excess carbon dioxide added to the atmosphere through the combustion of fossil fuels interferes with the health of phytoplankton which form the base of marine food webs. Phytoplankton are microscopic plants whose growth in ocean surface waters supports ocean food webs and global marine fisheries. They are also key...
Signature Infiltration and Maintenance on Plasmid Elements creating a Forensic Microbial System (SIMPLE-FMS)
J. Craig Venter Institute (JCVI) is developing a unique microbial barcode (“signature”) that can be easily be deployed in complex environments to create unique microbial signatures for environmental forensics operations. The barcoded signature will be 1) maintained for specific amounts of time in a complex microbial community (microbiome) with minimal disturbance to the native environment; 2) transferable to a diverse array of objects; and 3) contained through control mechanisms...
JCVI Rockville Directions
J. Craig Venter Institute 9605 Medical Center Drive, Suite 150 Rockville, MD 20850 Phone: 301-795-7000 Driving Directions From Baltimore, MD and BWI Airport Take I-95 South to I-495 West (Silver Spring). Follow I-495 West nine miles to I-270 and travel north to Shady Grove Road (Exit 8 West). Continue to the traffic light and turn left onto Shady Grove Road. Make a right at the 4th light onto Key West Ave. (MD 28...
JCVI La Jolla Directions
J. Craig Venter Institute 4120 Capricorn Lane La Jolla, CA 92037 Phone: 858-200-1800 Driving Directions From the South on I-5 (from San Diego Airport) Take the La Jolla Village Drive exitTurn left onto La Jolla Village Drive Stay in left-most non-turn lane Enter left turn lane after Torrey Pines Road intersection Turn left onto Expedition Way Immediate first left is Capricorn Lane Continue to JCVI building From the North on I-5 (from John Wayne...