Search
Genomic and Antigenic Analysis of Seasonal H3N2 Influenza a Virus From 2012-2013
Haley Hochstein1, Karla M. Stucker1, Seth Schobel2, Xudong Lin1, Randall J. Olsen3, Anju Subba1, Rebecca A. Halpin1, Asmik Akopov1, Nadia Fedorova1, Timothy B. Stockwell2, James M. Musser3, Suman R. Das1, David E. Wentworth1 1Virology Group and 2Informatics Department, J. Craig Venter Institute, Rockville, MD 20850 3Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX 77030 Influenza is an acute viral...
Generating a Library of Influenza a Virus Hemagglutanin and Neuraminidase Genes
Titas Bera, Anthony Bennici, Haley Hochstein, Karla M. Stucker, Suman R. Das, David E. Wentworth Virology Group, J. Craig Venter Institute, Rockville, MD 20850 Every year, five to twenty percent of the United States population is infected with seasonal influenza, making the construction of a seasonal vaccine of high importance. However, due to antigenic drift among seasonal influenza viruses, the vaccine strains need frequent updating. Antigenic drift occurs as the genes encoding...
Sequence-independent Amplification of Rotaviruses for High-throughput Next-generation Sequencing
Anthony K. Bennici1, Karla M. Stucker1, Asmik Akopov1, Nadia Fedorova1, Rebecca A. Halpin1, Timothy B. Stockwell2, David E. Wentworth 1Virology Group and 2Informatics Department, J. Craig Venter Institute, Rockville, MD 20850 Rotavirus is a segmented dsRNA virus that causes gastroenteritis and is the primary cause of severe pediatric diarrhea, which results in over half a million deaths per year globally. There are eight known species of rotaviruses (A-H) that infect humans and...
Translational Health Science and Technology Institute (THSTI) Training
In September 6-8, 2017, Translational Health Science and Technology Institute (THSTI), NIAID Division of Microbiology and Infectious Diseases (DMID) , NIAID PATRIC Bioinformatics Resource Center/University of Chicago and NIAID Genomic Center for Infectious Diseases at J. Craig Venter Institute participated in three days training in Delhi, India for Indo-US Workshop on Genomics and Bioinformatics to Explore Human Microbiome Ecology in Health and Diseases. The Translational Health Science and...
Key Biological Mechanism is Disrupted by Ocean Acidification
A team led by scientists from Scripps Institution of Oceanography at the University of California San Diego and the J. Craig Venter Institute (JCVI) has demonstrated that the excess carbon dioxide added to the atmosphere through the combustion of fossil fuels interferes with the health of phytoplankton which form the base of marine food webs. Phytoplankton are microscopic plants whose growth in ocean surface waters supports ocean food webs and global marine fisheries. They are also key...
Signature Infiltration and Maintenance on Plasmid Elements creating a Forensic Microbial System (SIMPLE-FMS)
J. Craig Venter Institute (JCVI) is developing a unique microbial barcode (“signature”) that can be easily be deployed in complex environments to create unique microbial signatures for environmental forensics operations. The barcoded signature will be 1) maintained for specific amounts of time in a complex microbial community (microbiome) with minimal disturbance to the native environment; 2) transferable to a diverse array of objects; and 3) contained through control mechanisms...
JCVI Rockville Directions
J. Craig Venter Institute 9605 Medical Center Drive, Suite 150 Rockville, MD 20850 Phone: 301-795-7000 Driving Directions From Baltimore, MD and BWI Airport Take I-95 South to I-495 West (Silver Spring). Follow I-495 West nine miles to I-270 and travel north to Shady Grove Road (Exit 8 West). Continue to the traffic light and turn left onto Shady Grove Road. Make a right at the 4th light onto Key West Ave. (MD 28...
JCVI La Jolla Directions
J. Craig Venter Institute 4120 Capricorn Lane La Jolla, CA 92037 Phone: 858-200-1800 Driving Directions From the South on I-5 (from San Diego Airport) Take the La Jolla Village Drive exitTurn left onto La Jolla Village Drive Stay in left-most non-turn lane Enter left turn lane after Torrey Pines Road intersection Turn left onto Expedition Way Immediate first left is Capricorn Lane Continue to JCVI building From the North on I-5 (from John Wayne...
Past encounters with the flu shape vaccine response
UNIVERSITY OF CHICAGO MEDICAL CENTER New research on why the influenza vaccine was only modestly effective in recent years shows that immune history with the flu influences a person's response to the vaccine. Low effectiveness of the flu vaccine is often blamed on problems with how the vaccine is designed and produced. Sometimes the flu strains chosen for the vaccine are a poor match for those that end up circulating in the public, especially in years when the H3N2 strain predominates....
Social behaviour and gut microbiota in red-bellied lemurs (Eulemur rubriventer): In search of the role of immunity in the evolution of sociality.
Vertebrate gut microbiota form a key component of immunity and a dynamic link between an individual and the ecosystem. Microbiota might play a role in social systems as well, because microbes are transmitted during social contact and can affect host behaviour. Combining methods from behavioural and molecular research, we describe the relationship between social dynamics and gut microbiota of a group-living cooperative species of primate, the red-bellied lemur (Eulemur rubriventer)....