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Characterization of Prochlorococcus clades from iron-depleted oceanic regions.
Prochlorococcus describes a diverse and abundant genus of marine photosynthetic microbes. It is primarily found in oligotrophic waters across the globe and plays a crucial role in energy and nutrient cycling in the ocean ecosystem. The abundance, global distribution, and availability of isolates make Prochlorococcus a model system for understanding marine microbial diversity and biogeochemical cycling. Analysis of 73 metagenomic samples from the Global Ocean Sampling expedition acquired in...
S2 Genomics Awarded $280,000 Phase I STTR Grant from the National Institutes of Health
LIVERMORE, CA – June 26, 2018 – S2 Genomics, Inc. has received a $280,000 Phase I STTR grant (1 R41 HG010129-01) from the National Institutes of Health’s National Human Genome Research Institute to develop the Singulator™ system for automated preparation of single cells or single nuclei suspensions from solid tissue samples. The system will include single-use sample cartridges and proprietary reagents that allow researchers to isolate cells or nuclei rapidly,...
DNA repeats identify novel virulence genes in Haemophilus influenzae.
The whole genome sequence (1.83 Mbp) of Haemophilus influenzae strain Rd was searched to identify tandem oligonucleotide repeat sequences. Loss or gain of one or more nucleotide repeats through a recombination-independent slippage mechanism is known to mediate phase variation of surface molecules of pathogenic bacteria, including H. influenzae. This facilitates evasion of host defenses and adaptation to the varying microenvironments of the host. We reasoned that iterative nucleotides could...
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.
Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130-140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free assemblies (contigs) of 3.6 and 16 megabases (Mb). The latter represents the longest published stretch of uninterrupted DNA sequence assembled from any organism to date. Chromosome 2 represents 15% of the genome and encodes 4,037...
Scientists Decipher Genetic Code of Malaria Parasite
October 2, 2002 Rockville, MD - In a landmark contribution to the age-old battle against malaria, a consortium of scientists including The Institute for Genomic Research (TIGR) announced today that they have deciphered the complex genetic code of the parasite that causes the deadliest form of the disease. Malaria is one of the world's most devastating infectious diseases, killing more than a million people a year in developing nations. The scientific paper analyzing the genome of that...
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.
Virulence and immunity are poorly understood in Mycobacterium tuberculosis. We sequenced the complete genome of the M. tuberculosis clinical strain CDC1551 and performed a whole-genome comparison with the laboratory strain H37Rv in order to identify polymorphic sequences with potential relevance to disease pathogenesis, immunity, and evolution. We found large-sequence and single-nucleotide polymorphisms in numerous genes. Polymorphic loci included a phospholipase C, a membrane lipoprotein,...
About Thomas Ishoey
Thomas is a passionate and innovative technologist with expertise in early-stage technology development and commercialization. He has held several C-level and senior management positions and demonstrated turn-around and team building capability across multiple disciplines.
Scientist Spotlight: Lauren Oldfield
Since high school, Lauren Oldfield, PhD found that science was her calling. It started with a love of reading encouraged by her mom and grandmother, both avid readers, and weekly trips to the public library. Books by Michael Crichton and Richard Preston were staples in her grandmother’s collection. After devouring “The Hot Zone,” a fictionalized account of an almost outbreak of Ebola in the United States, microbiology and the study of infectious diseases became her passion....
Genome Solver Annotation Workshops
The Human Microbiome Project (HMP) has created a wealth of new questions for scientists. However, the current rate of microbial DNA sequencing far outpaces the ability of experts to analyze the genomes and metagenomes that have resulted from the HMP, creating a need for additional hands and minds to deal with the myriad of questions. This need in turn creates an opportunity for undergraduates to get involved in research on the HMP. Through the National Science Foundation (NSF) TUES...
Back To Sampling In The Black Sea and Rough Rough Weather
September 9th 2010 Hello everyone! I know it has been a long time since the last post from Sorcerer II. Let me take the time to explain…………..in early August we sailed to Greece. As I have mentioned in the past we have permits with each country to collect samples, these permits have certain time windows and other country specific stipulations. Once stipulation on the Greek permit was that for each Greek sample collected we must have a Greek collaborator onboard Sorcerer II. One...