Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins
Chen CJ, Ermler ME, Tan GS, Krammer F, Palese P, Hai R
A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.
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