Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.

Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.

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Authors: Lin Z, Phadke S, Lu Z, Beyhan S, Abdel Aziz MH, Reilly C, Schmidt EW
Title: Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.
Citation: Journal of natural products. 2018-12-28; 81.12: 2605-2611.
Abstract:
We report an unusual 3-substituted pyridine polyketide, onydecalin A (1), which was obtained along with 2 as a major constituent from the fungus Aioliomyces pyridodomos (order: Onygenales) following a two-month fermentation. Feeding studies demonstrated that the pyridine subunit originates via an unprecedented biosynthetic process in comparison to other polyketide-linked pyridines or derivatives such as pyridones. The slow growth of the fungus led us to perform a one-year fermentation, leading to production of compounds 2-4 as the major constituents. These compounds showed modest but selective inhibition against a variety of transient receptor potential channels, as well as against the human pathogenic fungus Histoplasma capsulatum.
PMID: 30507122