Genome Properties

The Genome Properties system consists of a suite of "Properties" which are carefully defined attributes of prokaryotic organisms whose status can be described by numerical values or controlled vocabulary terms for individual completely sequenced genomes. The Genome Properties database, specifies how computed evidence, including TIGRFAMs HMM results, should be used to judge whether an enzymatic pathway, a protein complex or another type of molecular subsystem is encoded in a genome. TIGRFAMs and Genome Properties content are developed in concert because subsystems reconstruction for large numbers of genomes guides selection of seed alignment sequences and cutoff values during protein family construction. Both databases specialize heavily in bacterial and archaeal subsystems.


PloS one. 2017-01-01; 12.6: e0171758.
A comprehensive software suite for protein family construction and functional site prediction
Haft DR, Haft DH
PMID: 28182651
Nucleic acids research. 2013-01-01; 41.Database issue: D387-95.
TIGRFAMs and Genome Properties in 2013
Haft DH, Selengut JD, Richter RA, Harkins D, Basu MK, Beck E
PMID: 23197656
Nucleic acids research. 2007-01-01; 35.Database issue: D260-4.
TIGRFAMs and Genome Properties: tools for the assignment of molecular function and biological process in prokaryotic genomes
Selengut JD, Haft DH, Davidsen T, Ganapathy A, Gwinn-Giglio M, Nelson WC, Richter AR, White O
PMID: 17151080
Bioinformatics (Oxford, England). 2005-02-01; 21.3: 293-306.
Genome Properties: a system for the investigation of prokaryotic genetic content for microbiology, genome annotation and comparative genomics
Haft DH, Selengut JD, Brinkac LM, Zafar N, White O
PMID: 15347579


This project was funded through National Science Foundation, grant number 1458808.

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