Relationship Between the Oral Microbiome and Caries Status of Young Twins

Host genetics and environmental factors have a significant impact on the oral microbiome. However, such external factors influencing the oral microbiome have yet to be investigated thoroughly using meta-omics approaches. Our study focuses on determining the links between early environment (shared and nonshared), genetics, epigenetics, and caries development. Our goals include characterizing the species and strains of dental plaque collected from twin pairs during a longitudinal study, characterizing the functional component of these samples with metagenomics and metatranscriptomics sequencing, and determining the link between host genetics and caries development—particularly in caries concordant and discordant twins.


Longitudinal Study of Oral Microbiome Variation in Twins.
Scientific reports. 2020-05-14; 10.1: 7954.
PMID: 32409670
Supragingival Plaque Microbiome Ecology and Functional Potential in the Context of Health and Disease.
mBio. 2018-11-27; 9.6:
PMID: 30482830
Host Genetic Control of the Oral Microbiome in Health and Disease.
Cell host & microbe. 2017-09-13; 22.3: 269-278.e3.
PMID: 28910633
The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health.
Microbial ecology. 2017-02-01; 73.2: 492-503.
PMID: 27628595


Funding for this project provided through the National Institute of Dental and Craniofacial Research (NIDCR).

Key Staff

  • Claire Kuelbs


Toby Hughes
Adelaide Dental Hospital

Jeffrey Craig
Murdoch Children’s Research Institute

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