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A Pilot Gut Microbiome study to evaluate TEDDY Infectious Agents
Type 1 Diabetes mellitus (T1D) is an autoimmune disorder characterized by a loss of function of insulin producing beta cells in pancreatic islets of langerhans leading to insulin insufficiency. Published studies have suggested that T1D results from environmental triggers acting on genetically susceptible individuals and that microbial infection and their immunological consequences are suspected to take part in the pathogenesis. Altered microbial diversity in the gut microbiota has been shown to...
First Self-Replicating Synthetic Bacterial Cell
Genomic science has greatly enhanced our understanding of the biological world. It is enabling researchers to "read" the genetic code of organisms from all branches of life by sequencing the four letters that make up DNA. Sequencing genomes has now become routine, giving rise to thousands of genomes in the public databases. In essence, scientists are digitizing biology by converting the A, C, T, and G's of the chemical makeup of DNA into 1's and 0's in a computer. But can one reverse the...
Global Ocean Sampling Expedition (GOS)
Overview In 2004, after a successful pilot project of shotgun metagenomics sequencing at the Bermuda Atlantic Time Series site, J. Craig Venter, PhD, and a Venter Institute team launched the Sorcerer II Global Ocean Sampling (GOS) Expedition. Inspired by 19th Century sea voyages like Darwin's on the H.M.S. Beagle and Captain George Nares on the H.M.S. Challenger, The Sorcerer II circumnavigated the globe for more than two years, covering a staggering 32,000 nautical miles, visiting 23...
Systems Biology for Molecular Analysis of Tuberculosis in Ethiopia
Mycobacterium tuberculosis (Mtb) is estimated to have infected one third of the world’s population based on reports from surveys on positive skin tuberculin tests. There are 22 high-burden countries globally, among them Ethiopia, accounting for 80% of all active tuberculosis cases. The clonal relatedness of strains circulating in humans and other potential reservoirs is poorly understood. Molecular epidemiology is gaining importance in tracking strains and addressing key public health...
Human Microbiome
Both inside and out, our bodies harbor a huge array of bacteria and other microorganisms collectively known as the human microbiome. Although bacteria are often thought to be dangerous, many of those that comprise the microbiome are essential for life. Our researchers are focused on understanding the delicate bacterial balance in the human body and how slight changes in that balance can either improve health or lead to diseases. JCVI Human Microbiome Research Impact Since the...
Acknowledgement of Data Use
Notice and Disclaimer/Limitation of Liability Data and information released from J. Craig Venter Institute (JCVI) are provided on an "AS IS" basis, without warranty of any kind, including without limitation the warranties of merchantability, fitness for a particular purpose and non-infringement. Availability of this data and information does not constitute scientific publication. Data and/or information may contain errors or be incomplete. JCVI and its employees make no representation or...
Internet Usage & Privacy Statement
The J. Craig Venter Institute (JCVI) has several domain names which can be used to access JCVI web sites (Site or Sites). Such domain names include jcvi.org, tigr.org and other JCVI domain names. These Sites are controlled, operated and maintained by JCVI personnel in connection with JCVI business. Please read this statement carefully before accessing any Sites or conducting any transaction available at Sites. By using any of the Sites the user signifies that they have read this statement and...
Science Education Program
Overview The JCVI science education program provides broad-based community resources for science education and professional development to students, teachers, and scientists. We believe that some of the most valuable contributions our researchers make are outside of the lab, connecting with our communities and other scientists, to inspire and encourage exploration of the wonder and potential of the natural world. We are committed to providing access to science for all. Our mission is...
JCVI La Jolla: Sustainable Laboratory Facility
A Seamless Integration of Scientific Vision, Purpose and Technology JCVI’s commitment to environmental stewardship inspired the design and construction of our West Coast home: a unique, LEED Platinum biological laboratory building that generates almost all of the energy it consumes from the solar panels on its roof. Located on the campus of the UC San Diego, JCVI La Jolla contains some of the most innovative water and energy-efficient systems available, and, most importantly, is serving...
About J. Craig Venter Institute
Pioneering Genomics to Positively Impact Life The J. Craig Venter Institute (JCVI) is a world leader in genomic research with approximately 120 scientists and staff who are bold innovators fearlessly pursuing revolutionary ideas. With a long track record of creativity and an interdisciplinary approach to genomics, JCVI is committed to accelerating foundational scientific research to drive advances in human health and environmental sustainability. As part of JCVI’s core mission since our...