Bio

Tae Seok Moon, Ph.D. is a professor at J. Craig Venter Institute in the synthetic biology group. Prior or joining JCVI, he was a professor at Washington University in St. Louis in the McKelvey School of Engineering. His research goals are to understand and engineer biological networks that genes and cellular processes use to solve energy, environmental, agricultural, and health problems. He has a broad background in systems and synthetic biology, with expertise in the development of engineered cells for practical applications.

His body of work includes engineering probiotic bacteria for medical applications, engineering bacteria to enable efficient production of biofuels, biomaterials, and chemicals from biomass and waste plastics, developing biocontainment strategies to prevent the spread of GMOs in the environment, building application-relevant biosensors and dynamic sensor-regulators, understanding and engineering microbiota and microbiota-host interactions using computational and experimental approaches, engineering biology for space exploration and engineered living materials, preventing antibiotic resistance spread by implementing engineering approaches, and engineering predictable RNA regulators.

Dr. Moon is committed to mentoring young researchers. In addition to students and postdoctoral researchers in his lab, he has mentored iGEM student teams and provided teaching kits to high school teachers and K-12 students. He founded and administers the weekly SynBYSS seminar series, which features a rising young scientist paired with a seasoned investigator. He is also the chair of the inaugural in-person SynBYSS conference.

Dr. Moon earned his BS and MS in chemical technology from Seoul National University in Seoul, Korea, and a Ph.D. under the guidance of Kristala Prather in chemical engineering with a minor in biological chemistry from Massachusetts Institute of Technology (MIT). He then completed a postdoctoral fellowship in the Christopher Voigt Group in the Department of Biological Engineering & Synthetic Biology Center at MIT and in the Department of Pharmaceutical Chemistry at the University of California-San Francisco.

Publications

Publications

Cell reports methods. 2026-05-05; 101430.

Resilience of recombinant antibiotic resistance gene-containing plasmids against common cell culture disposal methods

Gluth A, Zmasek C, Chiu S, Moon TS
PMID: 42092359

Nature communications. 2025-01-16; 16.1: 728.

Developing an alternative medium for in-space biomanufacturing

Lee H, Diao J, Tian Y, Guleria R, Lee E, Smith A, Savage M, Yeh D, Roberson L, Blenner M, Tang YJ, Moon TS
PMID: 39819985

Biotechnology advances. 2024-12-01; 77.108462.

The current progress of tandem chemical and biological plastic upcycling

Hu Y, Tian Y, Zou C, Moon TS
PMID: 39395608

Trends in biotechnology. 2024-11-23;

Producing multiple chemicals through biological upcycling of waste poly(ethylene terephthalate)

Diao J, Tian Y, Hu Y, Moon TS
PMID: 39581772

New biotechnology. 2024-05-25; 80.69-71.

Earth: Extinguishing anthropogenic risks through harmonization

Moon TS
PMID: 38367910

New biotechnology. 2023-12-25; 78.150-152.

EBRC: Enhancing bioeconomy through research and communication

Moon TS
PMID: 37918664

Cell systems. 2023-12-20; 14.12: 1024-1043.

Advances in ligand-specific biosensing for structurally similar molecules

Xi C, Diao J, Moon TS
PMID: 38128482

Cell reports methods. 2023-12-18; 3.12: 100669.

Engineering E. coli strains using antibiotic-resistance-gene-free plasmids

Amrofell MB, Rengarajan S, Vo ST, Ramirez Tovar ES, LoBello L, Dantas G, Moon TS
PMID: 38086386

Frontiers in bioengineering and biotechnology. 2023-12-13; 11.1340377.

Editorial: CRISPR-aided bioengineering for value-added product development

Bandyopadhyay A, Köpke M, Moon TS
PMID: 38152286

PLoS computational biology. 2023-12-07; 19.12: e1011652.

Ten simple rules for managing laboratory information

Berezin CT, Aguilera LU, Billerbeck S, Bourne PE, Densmore D, Freemont P, Gorochowski TE, Hernandez SI, Hillson NJ, King CR, Köpke M, Ma S, Miller KM, Moon TS, Moore JH, Munsky B, Myers CJ, Nicholas DA, Peccoud SJ, Zhou W, Peccoud J
PMID: 38060459

PLoS biology. 2023-10-20; 21.10: e3002180.

Microbial thermogenesis is dependent on ATP concentrations and the protein kinases ArcB, GlnL, and YccC

Dhatt PS, Chiu S, Moon TS
PMID: 37862351

Trends in biotechnology. 2023-09-01; 41.9: 1099-1105.

Impacting future generations of synthetic biologists by ensuring diversity, equity, and inclusion

Moon TS, Solomon K, Borodina I, Vickers C
PMID: 37105777

ACS synthetic biology. 2023-06-16; 12.6: 1868-1873.

Characterizing a Propionate Sensor in E. coli Nissle 1917

Amrofell MB, Moon TS
PMID: 37220256

ACS synthetic biology. 2023-06-16; 12.6: 1632-1644.

A High-Quality Genome-Scale Model for Rhodococcus opacus Metabolism

Roell GW, Schenk C, Anthony WE, Carr RR, Ponukumati A, Kim J, Akhmatskaya E, Foston M, Dantas G, Moon TS, Tang YJ, García Martín H
PMID: 37186551

ACS synthetic biology. 2023-06-16; 12.6: 1583-1585.

SynHEAL: Synthesis of Health Equity, Advancement, and Leadership

Moon TS
PMID: 37322888

Nature chemical biology. 2023-05-01; 19.5: 544-545.

Mining microbial metabolism

Tang YJ, Moon TS
PMID: 36747057

Cell reports. 2023-01-31; 42.1: 111908.

Upcycling of poly(ethylene terephthalate) to produce high-value bio-products

Diao J, Hu Y, Tian Y, Carr R, Moon TS
PMID: 36640302

Proceedings of the National Academy of Sciences of the United States of America. 2023-01-03; 120.1: e2213154120.

Computational design of CRISPR guide RNAs to enable strain-specific control of microbial consortia

Rottinghaus AG, Vo S, Moon TS
PMID: 36574681

Trends in biotechnology. 2022-12-01; 40.12: 1405-1414.

SynMADE: synthetic microbiota across diverse ecosystems

Moon TS
PMID: 36117027

Communications biology. 2022-10-19; 5.1: 1109.

Deciphering the transcriptional regulation of the catabolism of lignin-derived aromatics in Rhodococcus opacus PD630

Diao J, Carr R, Moon TS
PMID: 36261484

Biodesign research. 2022-09-08; 2022.9806979.

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters

Kim S, Bajaj T, Chabon C, Tablante E, Kulchinskaya T, Moon TS, Bajaj R
PMID: 37850125

Nature chemical biology. 2022-04-01; 18.4: 353.

Making space for young speakers

Moon TS
PMID: 35352064

Cell systems. 2022-03-16; 13.3: 204-214.e4.

Engineering ligand-specific biosensors for aromatic amino acids and neurochemicals

Rottinghaus AG, Xi C, Amrofell MB, Yi H, Moon TS
PMID: 34767760

ACS synthetic biology. 2022-02-18; 11.2: 522-527.

Making Security Viral: Shifting Engineering Biology Culture and Publishing

Mackelprang R, Adamala KP, Aurand ER, Diggans JC, Ellington AD, Evans SW, Fortman JLC, Hillson NJ, Hinman AW, Isaacs FJ, Medford JI, Mamaghani S, Moon TS, Palmer MJ, Peccoud J, Vitalis EA, Hook-Barnard I, Friedman DC
PMID: 35176864

Nature communications. 2022-02-03; 13.1: 672.

Genetically stable CRISPR-based kill switches for engineered microbes

Rottinghaus AG, Ferreiro A, Fishbein SRS, Dantas G, Moon TS
PMID: 35115506

Environmental science & technology. 2021-06-15; 55.12: 8045-8053.

Duplex Structure of Double-Stranded RNA Provides Stability against Hydrolysis Relative to Single-Stranded RNA

Zhang K, Hodge J, Chatterjee A, Moon TS, Parker KM
PMID: 34033461

ACS synthetic biology. 2021-04-16; 10.4: 786-798.

An Improved CRISPR Interference Tool to Engineer Rhodococcus opacus

DeLorenzo DM, Diao J, Carr R, Hu Y, Moon TS
PMID: 33787248

Projects

News

08-May-2026
Press Release

Study finds DNA carrying antibiotic resistance genes can remain functional after common lab decontamination steps

Builds on JCVI’s longstanding leadership in biosafety, biosecurity, and bioethics

31-Jan-2025
Press Release

Revolutionizing plastic waste management through biological upcycling

Innovative research transforms plastic waste into valuable chemicals, paving the way for a circular economy and sustainable space travel

02-Oct-2024
Press Release

J. Craig Venter Institute awarded 5-year, $5M grant to lead Center for Innovative Recycling and Circular Economy (CIRCLE)

CIRCLE is one of the six new NSF Global Centers focused on advancing bioeconomy research to solve global challenges

01-May-2024

Tae Seok Moon, Ph.D. and Nan Zhu, Ph.D. join J. Craig Venter Institute faculty

JCVI continues to actively recruit faculty to expand core research areas, including human health and synthetic biology