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Genome of Deadly Amoeba Shows Surprising Complexity; Study Reveals Evidence for Lateral Gene Transfer from Bacteria
The genome sequence of the parasitic amoeba Entamoeba histolytica, a leading cause of severe diarrheal disease in developing countries, includes an unexpectedly complex repertoire of sensory genes as well as a variety of bacterial-like genes that contribute to the organism's unique biology. TIGR scientists led the project, which presents the first genome-wide study of an amoeba. About 50 million people a year are infected by the parasite, which causes as many as 100,000 deaths annually.
Scientists Decipher Genome of a Fungus That Causes Life-Threatening Infections in Persons With Impaired Immunity
Cryptococcus Study Sheds Light On How Fungi Cause Disease
Scientists Reveal Molecular Secrets of the Malaria Parasite
Groundbreaking Research Project May Help Boost Vaccine Development
Scientists Decipher Genome of Bacterium that Helps Clean Up Major Groundwater Pollutants
Cryptococcus Study Sheds Light On How Fungi Cause Disease
Genome Comparison of Four Campylobacter Strains Yields New Genetic Markers and Clues to Virulence
In a study that could benefit medical and food-safety research, scientists have used the tools of comparative genomics to find new clues about why some strains of the bacterium Campylobacter - which each year cause more than 400 million cases of gastrointestinal disease - are more virulent than others. The analysis is helping researchers develop more comprehensive detection methods for analyzing human and environmental isolates of the bacteria.
Microbe's Genome Reveals Insights Into Ocean Ecology
Unexpected findings about the genetic makeup of a marine microbe have given scientists a new perspective on how bacteria make a living in the ocean - a view that may prove useful in wider studies of marine ecology. The analysis by TIGR and collaborators of the DNA sequence of Silicibacter pomeroyi found that the metabolic strategies of marine bacterioplankton are more diverse and less conventional than previously thought.
Innovative Metagenomics Strategy Used To Study Oral Microbes
In an innovative new project, TIGR scientists and collaborators are using a metagenomics strategy to explore the complex mix of microbes in the human mouth. The research could help improve the diagnosis and treatment of periodontitis and other oral diseases.
Influenza Genome Sequencing Project Is Launched
TIGR will sequence a large number of human isolates of the influenza virus as part of a landmark influenza genome sequencing project announced Monday by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The project aims to help scientists better understand how flu viruses evolve as they spread through the population.
TIGR and Virginia Tech Sign Memorandum for New Alliance
A new alliance between TIGR and Virginia Tech University is expected to enhance the Institute's computational and experimental capacity as well as enrich the university's basic research in the life sciences. The Memorandum of Understanding, announced Monday, anticipates joint research projects, shared use of related facilities, adjunct faculty appointments, and opportunities for students to participate in research.
TIGR's Fraser, Salzberg Honored As AAAS Fellows
TIGR President Claire M. Fraser and Senior Bioinformatics Director Steven L. Salzberg have been named as Fellows of the American Association for the Advancement of Science (AAAS) in recognition of their contributions to genomics and bioinformatics.
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PRIDE in STEM
Updated 2023-06-09 AT JCVI, we know first-hand that a career in science and technology can be a fulfilling and rewarding way for individuals to make a real impact on the world around us. The STEM fields are shaping our lives and are fueling social progress. The involvement of LGBTQ+...
Supporting earthquake relief efforts in Turkey and Syria
We are devastated by the recent earthquakes which have caused enormous destruction in Turkey and Syria and encourage all who are able to support organizations involved in relief efforts. Locally, the American Turkish Association of Southern California (ATASC) is raising funds and...
Leg 2: exploring the Mid-Cayman Spreading Center
Editor’s note JCVI Staff Scientist Erin Garza, Ph.D., was selected to embark on a unique research expedition aboard the HOV Alvin submersible, a crewed deep-ocean research vessel owned by the United States Navy and operated by the Woods Hole Oceanographic Institution, that has brought...
The dive: searching for deep ocean plastics in the Puerto Rico Trench
Editor’s note JCVI Staff Scientist Erin Garza, Ph.D., was selected to embark on a unique research expedition aboard the HOV Alvin submersible, a crewed deep-ocean research vessel owned by the United States Navy and operated by the Woods Hole Oceanographic Institution, that has brought...
Leg 1: headed to an unexplored area of the Puerto Rico Trench
Editor’s note JCVI Staff Scientist Erin Garza, Ph.D., was selected to embark on a unique research expedition aboard the HOV Alvin submersible, a crewed deep-ocean research vessel owned by the United States Navy and operated by the Woods Hole Oceanographic Institution, that has brought...
My journey begins: heading to the Puerto Rico Trench in search of deep-sea plastic
Editor’s note JCVI Staff Scientist Erin Garza, Ph.D., was selected to embark on a unique research expedition aboard the HOV Alvin submersible, a crewed deep-ocean research vessel owned by the United States Navy and operated by the Woods Hole Oceanographic Institution, that has brought...
Celebrating pioneers in science and medicine this Black History Month
Happy Black History Month! At JCVI, we believe in the importance of celebrating scientific trailblazers, particularly those who made groundbreaking advancements all while overcoming overt racism. Here, we have highlighted the stories and achievements of some of the most accomplished Black...
Eleven female scientists whose research changed the world
Today is Women’s Equality Day and to celebrate, we are highlighting accomplishments made by women in science and technology. While these scientists were influential in advancing their fields and championing the fair treatment of women in science, currently women only make up 28% of the...
Complete Genome Sequence of Strain JB001, a Member of Saccharibacteria Clade G6
The complexity and diversity of the microbial world was not fully understood until sequencing technology allowed us to study microbes without growing them in the lab. An important family of bacteria, Saccharibacteria (formerly called TM7), is one of the many bacteria of interest which were...
Scientific Pioneers
JCVI recognizes trailblazers in scientific history, particularly those who made advancements all while surpassing gender, ethnic, and other societal barriers, creating opportunity for the next generation of scientists. These historical figures not only helped advance our understanding of human...
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Even Synthetic Life Forms With a Tiny Genome Can Evolve
By watching “minimal” cells regain the fitness they lost, researchers are testing whether a genome can be too simple to evolve.
Privacy concerns sparked by human DNA accidentally collected in studies of other species
Two research teams warn that human genomic “bycatch” can reveal private information
Scientists Unveil a More Diverse Human Genome
The “pangenome,” which collated genetic sequences from 47 people of diverse ethnic backgrounds, could greatly expand the reach of personalized medicine.
First human ‘pangenome’ aims to catalogue genetic diversity
Researchers release draft results from an ongoing effort to capture the entirety of human genetic variation.
Scientists Create the Smallest-Ever Moving Cell
Just two genes get tiny synthetic cells moving, offering clues to life’s evolution.
From Sequencing to Sailing: Three Decades of Adventure with Craig Venter
In a plenary public appearance at the Molecular and Precision Med TRI-CON event in San Diego, a relaxed Venter reflected on his career highlights, controversies and future priorities for genomic medicine.
Synthesizing life on the planet
What’s the smallest number of genes that cells need to grow and reproduce? Is it possible to synthesize minimal genomes and insert them into cells? What do minimal genomes teach us about life? An interview with John Glass, Ph.D.
Top scientists join forces to study leading theory behind long COVID
Several JCVI scientists will be contributing to the newly launched Long Covid Research Initiative — a collaboration of researchers, clinicians, and patients working to rapidly study and treat long Covid.
Hunting for deep-ocean plastics
Through the Woods Hole Oceanographic Institution, National Deep Submergence Facility, JCVI's Erin Garza, Ph.D. joins a deep sea expedition to search for ocean plastics aboard the HOV Alvin.
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