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Genome Comparison of Four Campylobacter Strains Yields New Genetic Markers and Clues to Virulence
In a study that could benefit medical and food-safety research, scientists have used the tools of comparative genomics to find new clues about why some strains of the bacterium <em>Campylobacter</em> - which each year cause more than 400 million cases of gastrointestinal disease - are more virulent than others. The analysis is helping researchers develop more comprehensive detection methods for analyzing human and environmental isolates of the bacteria.
Microbe's Genome Reveals Insights Into Ocean Ecology
Unexpected findings about the genetic makeup of a marine microbe have given scientists a new perspective on how bacteria make a living in the ocean - a view that may prove useful in wider studies of marine ecology. The analysis by TIGR and collaborators of the DNA sequence of Silicibacter pomeroyi found that the metabolic strategies of marine bacterioplankton are more diverse and less conventional than previously thought.
Innovative Metagenomics Strategy Used To Study Oral Microbes
In an innovative new project, TIGR scientists and collaborators are using a metagenomics strategy to explore the complex mix of microbes in the human mouth. The research could help improve the diagnosis and treatment of periodontitis and other oral diseases.
Influenza Genome Sequencing Project Is Launched
TIGR will sequence a large number of human isolates of the influenza virus as part of a landmark influenza genome sequencing project announced Monday by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The project aims to help scientists better understand how flu viruses evolve as they spread through the population.
TIGR and Virginia Tech Sign Memorandum for New Alliance
A new alliance between TIGR and Virginia Tech University is expected to enhance the Institute's computational and experimental capacity as well as enrich the university's basic research in the life sciences. The Memorandum of Understanding, announced Monday, anticipates joint research projects, shared use of related facilities, adjunct faculty appointments, and opportunities for students to participate in research.
TIGR's Fraser, Salzberg Honored As AAAS Fellows
TIGR President Claire M. Fraser and Senior Bioinformatics Director Steven L. Salzberg have been named as Fellows of the American Association for the Advancement of Science (AAAS) in recognition of their contributions to genomics and bioinformatics.
Computational Genomics Conference To Attract Leading Scientists
Comparative genomics, sequence assembly, gene expression analysis and genome annotation are among the hot topics to be discussed at the 7th annual Conference on Computational Genomics, which will be held October 21-24 in Reston, VA. The meeting is jointly sponsored by TIGR and The Jackson Laboratory.
J. Craig Venter Announces Consolidation of Three Research Organizations Into One New Not-For-Profit Organization — The J. Craig Venter Institute
The Center for Advancement of Genomics (TCAG), Institute for Biological Energy Alternatives (IBEA), and J. Craig Venter Science Foundation Joint Technology Center (JTC) consolidated to form J. Craig Venter Institute
Scientists Decipher Genome of Biothreat Pathogen
Highly Regulated Virulence Genes and Genomic Instability Found in the Infectious Horse Pathogen Burkholderia mallei
Scientists Explore Genome of Methane-breathing Microbe
First Complete DNA Sequence of a Methanotroph Reveals Metabolic Flexibility, Suggests Mechanisms for Increasing Its Usefulness For Biotechnology
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Back To Sampling In The Black Sea and Rough Rough Weather
September 9th 2010 Hello everyone! I know it has been a long time since the last post from Sorcerer II. Let me take the time to explain…………..in early August we sailed to Greece. As I have mentioned in the past we have permits with each country to collect samples, these permits have...
Take home message of the 2010 Amebiasis Montreal Meeting: beware of who you kiss…
The Entamoeba community is a small and collegial one. Everyone knows everyone and everyone else wants to collaborate, and learn and do more to tackle down this neglected among neglected diseases. For many, the thought of an amoeba brings to memory Garry Larson’s The Far Side amorphous characters...
Entamoeba histolytica research presented at the Molecular Parasitology Meeting
Entamoeba histolytica causes invasive intestinal and extraintestinal infections, known as amoebiasis, in about 50 million people and still remains a significant cause of human death in developing countries. However, for unknown reasons, fewer than 10% of E. histolytica infections are symptomatic...
Virtual Comparative Metagenomics
We have created an open virtualization format (OVF) package of JCVI's Metagenomics Reports (METAREP)- a high performance comparative metagenomics analysis tool. The software runs on a web server, retrieves data from two different database systems and uses R for statistical analysis. The new OVF...
Italy: Sites and Sailing
Saturday July 31st When I last wrote we had finished our 10 day sampling window in Italian waters. On Wednesday July 21st we arrived in Rome the same day Dr. Venter, Heather Kowalski, and Darwin the super boat dog had flown in from the states. We spent 3 days in Rome, most of the time was spent...
10 Days of Italian Sampling Coming to a Close
Tuesday July 20th On July 16th we finished our Straits of Messina sampling and headed into the Ionian and Adriatic Seas. We sailed overnight and collected our Ionian Sea sample, we continued northeast and on July 18th we collected our Adriatic...
HMP Consortium - St. Louis Missouri
Human Microbiome Project Consortium – September 2010 – St Louis, Missouri We received warm welcome messages from Dr George Weinstock and Dr Jane Petersen as well as a humorous welcome from Dr Larry Shapiro, Dean of Washington University Medical School. It was wonderful to see so...
Straits of Messina Transect
Friday July 16th Today we woke up early and left our anchorage at Vulcano Island and headed to the Straits of Messina 20 miles away. The plan was to collect a sample at the north entrance, anchor for 5 hours to process the sample. Once the sample was completed then head to the middle of the...
Advance Access JCVI Metagenomics Reports Application Note
A significant JCVI informatics development is JCVI Metagenomics Reports, an open source Web 2.0 application designed to help scientists analyze and compare annotated metagenomics data sets. Users can download the application to upload and analyze their own metagenomics datasets. METAREP has...
Naples Harbor Sampling
Thursday July 15th After getting some sleep at anchorage in Ischia island we sailed for a few hours to the main harbor in Naples. Over the years the Sorcerer II Expedition has collected samples in major ports around the world (Sydney, Halifax, Boston, Panama, Cape Town, just to name...
Even Synthetic Life Forms With a Tiny Genome Can Evolve
By watching “minimal” cells regain the fitness they lost, researchers are testing whether a genome can be too simple to evolve.
Privacy concerns sparked by human DNA accidentally collected in studies of other species
Two research teams warn that human genomic “bycatch” can reveal private information
Scientists Unveil a More Diverse Human Genome
The “pangenome,” which collated genetic sequences from 47 people of diverse ethnic backgrounds, could greatly expand the reach of personalized medicine.
First human ‘pangenome’ aims to catalogue genetic diversity
Researchers release draft results from an ongoing effort to capture the entirety of human genetic variation.
Scientists Create the Smallest-Ever Moving Cell
Just two genes get tiny synthetic cells moving, offering clues to life’s evolution.
From Sequencing to Sailing: Three Decades of Adventure with Craig Venter
In a plenary public appearance at the Molecular and Precision Med TRI-CON event in San Diego, a relaxed Venter reflected on his career highlights, controversies and future priorities for genomic medicine.
Synthesizing life on the planet
What’s the smallest number of genes that cells need to grow and reproduce? Is it possible to synthesize minimal genomes and insert them into cells? What do minimal genomes teach us about life? An interview with John Glass, Ph.D.
Top scientists join forces to study leading theory behind long COVID
Several JCVI scientists will be contributing to the newly launched Long Covid Research Initiative — a collaboration of researchers, clinicians, and patients working to rapidly study and treat long Covid.
Hunting for deep-ocean plastics
Through the Woods Hole Oceanographic Institution, National Deep Submergence Facility, JCVI's Erin Garza, Ph.D. joins a deep sea expedition to search for ocean plastics aboard the HOV Alvin.
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