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Gene Tan is an assistant professor at the J. Craig Venter Institute working in the Infectious Disease group. The focus of his research is on virus-host interactions by defining the immunological, molecular and genetic determinants that govern immunity and disease. The aim is to better understand how viruses manipulate the host machinery to replicate and in turn elucidate the mechanisms by which the host counteracts the pathogen. Analyses of virus-host interaction can then facilitate the development of better diagnostic tools, novel therapeutics and vaccines.
Prior to his appointment at JCVI, Dr. Tan was a post-doctoral fellow at the Icahn School of Medicine at Mount Sinai working on characterizing the immunological and structural determinants of protection against influenza virus and Zika virus. He received his doctorate from Thomas Jefferson University and his undergraduate degree from the Philadelphia College of Pharmacy and Science.
Patents
Vaccines for use in the prophylaxis and treatment of influenza virus disease (Pat. No. US20170114103)
Research Priorities
Characterization of the structural and immunological determinants of protection against viral pathogens:
- Elucidate the mechanisms by which antibodies neutralize virus and protect in vivo.
- Emphasis on developing novel methods in isolating monoclonal antibodies from human peripheral blood mononuclear cell (PBMC) compartment.
Characterization of virus-host interaction by defining the molecular and transcriptional response
- Emphasis on respiratory and neurotropic pathogens.
Publications
Research Priorities
Characterization of the structural and immunological determinants of protection against viral pathogens:
- Elucidate the mechanisms by which antibodies neutralize virus and protect in vivo.
- Emphasis on developing novel methods in isolating monoclonal antibodies from human peripheral blood mononuclear cell (PBMC) compartment.
Characterization of virus-host interaction by defining the molecular and transcriptional response
- Emphasis on respiratory and neurotropic pathogens.
Genomics of West Nile Virus
Sequencing West Nile virus genomes isolated in the United States
Genomics of Chikungunya Virus
Sequencing Chikungunya virus genomes isolated from the Western hemisphere during the 2014 Caribbean outbreak
Genomics of Respiratory Syncytial Virus
Sequencing clinical isolates of Respiratory Syncytial Virus in various locations
Genomics of Influenza A and Influenza B Viruses
Sequencing Influenza genomes isolated from various hosts and locations
Genomics of Zika Virus
Investigating the genomics of Zika virus throughout the Americas
Vaccines and Therapeutics for Zika
Antigenic Map of Lyssavirus (Rabies Virus)
A Bioinformatics Roadmap for the Human Vaccines Project
Engineering a Self-Amplifying RNA Amplicon as a Vaccine or Therapeutic for Influenza
Age-Associated Determinants of Alveolar Macrophage-Mediated Antiviral and Inflammatory Responses
Influenza Research Database (IRD)
Virus Pathogen Resource (ViPR)
Influenza: Host-Virus-Microbiome Interactions
Genetic Diversity and Evolutionary Dynamics of Influenza A and B Viruses
Genetic Diversity and Evolutionary Dynamics of Eastern Equine Encephalitis Viruses (EEEV)
Genetic Diversity and Evolutionary Dynamics of Respiratory Syncytial Viruses (RSV)
Genetic Diversity and Evolutionary Dynamics of Rotaviruses
Impact of Viral Intra-Host Diversity on Transmission Dynamics and Antiviral Resistance
Genetic Diversity and Evolutionary Dynamics of West Nile Viruses
Respiratory Syncytial Virus: Host-Virus-Microbiome Interactions
Genomics of Eastern Equine Encephalitis Virus
Elucidating transmission of EEEV in the United States