Gene S. Tan, PhD

Assistant Professor

Gene Tan is an assistant professor at the J. Craig Venter Institute working in the Infectious Disease group. The focus of his research is on virus-host interactions by defining the immunological, molecular and genetic determinants that govern immunity and disease. The aim is to better understand how viruses manipulate the host machinery to replicate and in turn elucidate the mechanisms by which the host counteracts the pathogen. Analyses of virus-host interaction can then facilitate the development of better diagnostic tools, novel therapeutics and vaccines.

Prior to his appointment at JCVI, Dr. Tan was a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai working on characterizing the immunological and structural determinants of protection against influenza virus and Zika virus. He received his doctorate from Thomas Jefferson University and his undergraduate degree from the Philadelphia College of Pharmacy and Science.

Patents

Vaccines for use in the prophylaxis and treatment of influenza virus disease (Pat. No. US20170114103)

Publications

Chakraborty S, Gonzalez J, Edwards K, Mallajosyula V, Buzzanco AS, Sherwood R, Buffone C, Kathale N, Providenza S, Xie MM, Andrews JR, Blish CA, Singh U, Dugan H, Wilson PC, Pham TD, Boyd SD, Nadeau KC, Pinsky BA, Zhang S, Memoli MJ, Taubenberger JK, Morales T, Schapiro JM, Tan GS, Jagannathan P, Wang TT

Proinflammatory IgG Fc structures in patients with severe COVID-19.

Nature immunology. 2021-01-01; 22.1: 67-73.

PMID: 33169014

Phipps KL, Ganti K, Jacobs NT, Lee CY, Carnaccini S, White MC, Manandhar M, Pickett BE, Tan GS, Ferreri LM, Perez DR, Lowen AC

Collective interactions augment influenza A virus replication in a host-dependent manner.

Nature microbiology. 2020-09-01; 5.9: 1158-1169.

PMID: 32632248

Kaul D, Rathnasinghe R, Ferres M, Tan GS, Barrera A, Pickett BE, Methe BA, Das SR, Budnik I, Halpin RA, Wentworth D, Schmolke M, Mena I, Albrecht RA, Singh I, Nelson KE, García-Sastre A, Dupont CL, Medina RA

Author Correction: Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection.

Nature communications. 2020-06-16; 11.1: 3132.

PMID: 32546784

Kaul D, Rathnasinghe R, Ferres M, Tan GS, Barrera A, Pickett BE, Methe BA, Das SR, Das S, Budnik I, Halpin RA, Wentworth D, Schmolke M, Mena I, Albrecht RA, Singh I, Nelson KE, García-Sastre A, Dupont CL, Medina RA

Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection.

Nature communications. 2020-05-21; 11.1: 2537.

PMID: 32439901

Ramos I, Smith G, Ruf-Zamojski F, Martínez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, García-Sastre A, Fernandez-Sesma A

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.

Journal of virology. 2019-10-15; 93.20:

PMID: 31375585

Abreu-Mota T, Hagen KR, Cooper K, Jahrling PB, Tan G, Wirblich C, Johnson RF, Schnell MJ

Non-neutralizing antibodies elicited by recombinant Lassa-Rabies vaccine are critical for protection against Lassa fever.

Nature communications. 2018-10-11; 9.1: 4223.

PMID: 30310067

He W, Chen CJ, Mullarkey CE, Hamilton JR, Wong CK, Leon PE, Uccellini MB, Chromikova V, Henry C, Hoffman KW, Lim JK, Wilson PC, Miller MS, Krammer F, Palese P, Tan GS

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice.

Nature communications. 2017-10-10; 8.1: 846.

PMID: 29018261

He W, Tan GS, Mullarkey CE, Lee AJ, Lam MM, Krammer F, Henry C, Wilson PC, Ashkar AA, Palese P, Miller MS

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.

Proceedings of the National Academy of Sciences of the United States of America. 2016-10-18; 113.42: 11931-11936.

PMID: 27698132

Leon PE, He W, Mullarkey CE, Bailey MJ, Miller MS, Krammer F, Palese P, Tan GS

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact.

Proceedings of the National Academy of Sciences of the United States of America. 2016-10-04; 113.40: E5944-E5951.

PMID: 27647907

Henry Dunand CJ, Leon PE, Huang M, Choi A, Chromikova V, Ho IY, Tan GS, Cruz J, Hirsh A, Zheng NY, Mullarkey CE, Ennis FA, Terajima M, Treanor JJ, Topham DJ, Subbarao K, Palese P, Krammer F, Wilson PC

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection.

Cell host & microbe. 2016-06-08; 19.6: 800-13.

PMID: 27281570

Tan GS, Leon PE, Albrecht RA, Margine I, Hirsh A, Bahl J, Krammer F

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection.

PLoS pathogens. 2016-04-01; 12.4: e1005578.

PMID: 27081859

Chen CJ, Ermler ME, Tan GS, Krammer F, Palese P, Hai R

Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins.

Journal of virology. 2016-01-13; 90.7: 3789-93.

PMID: 26764009

Leyva-Grado VH, Tan GS, Leon PE, Yondola M, Palese P

Direct administration in the respiratory tract improves efficacy of broadly neutralizing anti-influenza virus monoclonal antibodies.

Antimicrobial agents and chemotherapy. 2015-07-01; 59.7: 4162-72.

PMID: 25941218

Henry Dunand CJ, Leon PE, Kaur K, Tan GS, Zheng NY, Andrews S, Huang M, Qu X, Huang Y, Salgado-Ferrer M, Ho IY, Taylor W, Hai R, Wrammert J, Ahmed R, García-Sastre A, Palese P, Krammer F, Wilson PC

Preexisting human antibodies neutralize recently emerged H7N9 influenza strains.

The Journal of clinical investigation. 2015-03-02; 125.3: 1255-68.

PMID: 25689254

Tan GS, Lee PS, Hoffman RM, Mazel-Sanchez B, Krammer F, Leon PE, Ward AB, Wilson IA, Palese P

Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin.

Journal of virology. 2014-12-01; 88.23: 13580-92.

PMID: 25210195

DiLillo DJ, Tan GS, Palese P, Ravetch JV

Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo.

Nature medicine. 2014-02-01; 20.2: 143-51.

PMID: 24412922

Tan GS, Krammer F, Eggink D, Kongchanagul A, Moran TM, Palese P

A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo.

Journal of virology. 2012-06-01; 86.11: 6179-88.

PMID: 22491456

Tan GS, Preuss MA, Williams JC, Schnell MJ

The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription.

Proceedings of the National Academy of Sciences of the United States of America. 2007-04-24; 104.17: 7229-34.

PMID: 17438267

Genomics of Rotavirus

Sequencing Rotavirus genomes isolated from around the world

Gene S. Tan, PhD

Related

Patents

Research Priorities

Characterization of the structural and immunological determinants of protection against viral pathogens:

Characterization of virus-host interaction by defining the molecular and transcriptional response

Publications

Genomics of Rotavirus

Genomics of Zika Virus

Genomics of West Nile Virus

Genomics of Influenza A and Influenza B Viruses

Genomics of Respiratory Syncytial Virus

Antigenic Map of Lyssavirus (Rabies Virus)

Vaccines and Therapeutics for Zika

Genomics of Chikungunya Virus

Coronavirus Research

A Bioinformatics Roadmap for the Human Vaccines Project

Age-Associated Determinants of Alveolar Macrophage-Mediated Antiviral and Inflammatory Responses

Engineering a Self-Amplifying RNA Amplicon as a Vaccine or Therapeutic for Influenza

Investigating Viral Disease to Develop Next Generation Vaccines and Therapeutics

Virus Pathogen Resource (ViPR)

Influenza Research Database (IRD)

Respiratory Syncytial Virus: Host-Virus-Microbiome Interactions

Genetic Diversity and Evolutionary Dynamics of Influenza A and B Viruses

Genetic Diversity and Evolutionary Dynamics of Eastern Equine Encephalitis Viruses (EEEV)

Genetic Diversity and Evolutionary Dynamics of Respiratory Syncytial Viruses (RSV)

Genetic Diversity and Evolutionary Dynamics of Rotaviruses

Impact of Viral Intra-Host Diversity on Transmission Dynamics and Antiviral Resistance

Genetic Diversity and Evolutionary Dynamics of West Nile Viruses

Influenza: Host-Virus-Microbiome Interactions

Genomics of Eastern Equine Encephalitis Virus

Unique Antibody Pattern Discovered in COVID-19 ICU Patients May Be Key to Predicting Severe Outcomes

COVID-19 Further Complicating Flu Season

Fighting Back Against Flu

J. Craig Venter Institute Education Program Fosters Learning Opportunities with Salisbury University Students and Faculty

In the News

Hamilton O. Smith, M.D., Synthetic Biology Pioneer and Nobel Laureate, to Step Down from Daily Duties at J. Craig Venter Institute

What's Happening

Unique Antibody Pattern Discovered in COVID-19 ICU Patients May Be Key to Predicting Severe Outcomes

Recently Published

A comprehensive and contemporary "snapshot" of β-lactamases in carbapenem resistant Acinetobacter baumannii.